Cutaneous Sarcoma Epigenetics

Epigenetic changes have an impact on a variety of physiological and pathological conditions in the human body. Recent advances in epigenetic studies of the skin have highlighted the significance of epigenetic modifications in skin diseases. Cutaneous sarcomas are incurable skin cancers with no curative treatment options for advanced forms. The detailed molecular effects of epigenetic modifications on skin sarcomas such as dermatofibrosarcoma protuberans, angiosarcoma, Kaposi's sarcoma, leiomyosarcoma, and liposarcoma are discussed in this review. We also go over the use of epigenetic-targeted therapy for skin sarcomas.

Keywords

Skin sarcoma; Epigenetics; Dermatofibrosarcoma protuberans; Angiosarcoma; Kaposi’s sarcoma; Leiomyosarcoma; Liposarcoma

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Cutaneous Sarcoma Epigenetics