Nia Rossiana*, Kartiawati Alipin, Keukeu Kaniawati Rosada, Mia Miranti Rosada, Annasa Rizki Kamalina
The aim of this study is obtaining sensitive extract to Enterococcus faecalis ATCC 29212, Eschericia coli ATCC 25922, and Salmonella typhimurium ATCC 49416, obtaining IC50 values and getting effective extract as colon anticancer with the HCT-116 cell line. This study use experimental and study literature. The measured parameter was the Inhibition Zone using disk diffusion, percentage of inhibition of HCT-116 cell lines using the MTT-assay method the data were analyzed profit to determine the IC50 value. The result study found that the largest inhibition zone of indicated bacterial test E. faecalis administered mushroom extract of the concentration studs 100mg/ml by 32.53 mm. IC50 value for Agaricus bisporus is 29.20 ppm and for Lentinula edodes is 6.11 ppm. According to U.S National Cancer Institute, the lower the IC50 value, the higher the cytotoxic activity. In summary ethyl acetate extract of fruit body sensitive to test bacterial, in anticancer test show that Lentinula edodes have more effectiveness to inhibit proliferation HCT-116.
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