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Systemic Lupus Erythematosus: Understanding the Complex Autoimmune Disease

Naresh Wagle

Systemic Lupus Erythematosus (SLE), commonly known as lupus, is a chronic autoimmune disease characterized by a dysregulated immune system attacking healthy tissues and organs. This article provides an overview of the causes, symptoms, diagnosis, and treatment options for lupus. The etiology of lupus involves genetic, hormonal, and environmental factors, although the exact cause remains unknown. Lupus can affect multiple organs, leading to a diverse range of symptoms such as fatigue, joint pain, skin rashes, and organ-specific complications. Diagnosis is challenging due to the variability of symptoms, but a combination of medical history, physical examinations, and laboratory tests can aid in the process. Treatment options aim to control symptoms, prevent flares, and minimize organ damage, and may include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, immunosuppressive drugs, and targeted biologic therapies. Lifestyle modifications, including sun protection, exercise, balanced diet, and stress management, complement medical treatment. Ongoing research holds promise for a better understanding of lupus and the development of personalized treatment approaches to improve patient outcomes and quality of life.


Systemic lupus erythematosus; Lupus; Autoimmune disease; Chronic; Immune system